Python was the earth-dragon of Delphi. He presided at the Delphic oracle, which existed in the cult center for his mother, Gaea.
Python became the chthonic enemy of the later Olympian deity Apollo, who slew him and remade Python's former home and the Oracle, the most famous in Ancient Greece, as his own.
Python is mentioned as having been revived by Gaea to once again oppose Apollo. Python's recapture of Delphi is named as one of Apollo's many failures in the Second Gigantomachy.
While traveling inside the Labyrinth, Apollo and Meg overhear a conversation between Python and Nero about the capture of other oracles.
- His name has been used as scientific names for a family and genus of snakes: Pythonidae and Python respectively.
- The Oracle of Delphi is named after his spouse Delphyne.